Olfactory dysfunction has been linked to age-related dementias (e.g., Alzheimer’s disease, vascular dementia, dementia in Parkinson’s disease, etc.)
Olfactory dysfunction has been linked to age-related dementias
This assignment will require you to do independent research of the relevant published literature.
A/B+ assignments typically cite 10-20 primary sources. APA format is require for in-text citations and the reference page.
For this assignment, answer both of the following questions.
Olfactory dysfunction has been link to age-relate dementias (e.g., Alzheimer’s disease, vascular dementia, dementia in Parkinson’s disease, etc.)
a) Provide a summary of the evidence for olfactory dysfunction in different types of dementia.
b) Describe the biological changes in dementia that may cause olfactory dysfunction to occur.
(maximum of 1000 words for question 1)
Total word count: 1500 words (excluding any in-text citations, reference list and title page).
Firstly, brain areas involved in olfactory processing — such as the olfactory bulb and entorhinal cortex — show very early neuropathology in Alzheimer disease (AD), suggesting that olfactory function is a potential biomarker.
Secondly, odour memory and odour identification are profoundly affect in individuals with AD and in those at risk of AD, suggesting that several measures of olfactory function signal preclinical AD.
Thirdly, Olfaction currently shows the greatest promise of all sensory biomarkers of AD; odour identification impairment predicts conversion to mild cognitive impairment (MCI) in cognitively normal individuals and conversion to AD in patients with amnestic MCI, and shows substantial relationships with other biomarkers of AD.
Further, epidemiological research indicates that hearing loss at baseline is associate with cognitive impairment and incident dementia over a 10-year period.
Also, visual changes in prodromal and clinical AD include retinal thinning in AD, impaired contrast sensitivity in AD and mild MCI, and abnormal pupillary responses that reflect cognitive load in AD and amnestic MCI.
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